HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 521468Generated: October 31, 2026
1,2-Dichloroethane → 2-(4-Methoxy-3-nitro-benzoylamino)-indane-2-carboxylic acid methyl ester
https://huagongshe.com/reaction/521468
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 4-Methoxy-3-nitrobenzoic acid | HCID 66640 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | methyl 2-amino-2,3-dihydro-1H-indene-2-carboxylate hydrochloride | HCID 45074056 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(4-Methoxy-3-nitro-benzoylamino)-indane-2-carboxylic acid methyl ester | HCID 67076671 | 65.6% |
Reaction Steps
To 2-amino-indane-2-carboxylic acid methyl ester hydrochloride (0.40 g, 1.77 mmol) and 4-methoxy-3-nitrobenzoic acid (0.35 g, 1.77 mmol) in 4 ml of DMF were added NMM (0.59 ml, 5.32 mmol), HOBT (0.31 g, 2.31 mmol) and EDC (0.44 g, 2.31 mmol). The mixture was stirred at 60° C. until LC/MS analysis showed complete conversion. The crude product was purified by silica gel chromatography (HEP/EA gradient) to give 0.43 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09328071B2 |
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| Source dataset | uspto-grants-2016_05 |
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| ORD ID | ord-d7f7620cbc314ee49e160a2b6e65936e |
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| Source note | uspto-grants-2016_05 |
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