HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-Acetoxy-4-trifluoromethyl-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 3-hydroxy-4-(trifluoromethyl)benzoic Acid | HCID 10943636 | — |
| Product | 3-Acetoxy-4-trifluoromethyl-benzoic acid | HCID 23616794 | — |
Reaction Steps
3.5 g (17 mmol) of 3-hydroxy-4-trifluoromethyl-benzoic acid (prepared as described in WO 2006/128184) were dissolved in 35 ml of acetic acid anhydride and heated to reflux for 3 h. 60 ml of water were added and heating to reflux was continued for 10 min. After cooling and stirring overnight, the formed precipitate was collected by suction and dried to give 3.0 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09328071B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-a667b6ea29d84951b6d72c1c00553de9 |
| Source note | uspto-grants-2016_05 |