2-(3-Hydroxy-4-methoxy-benzoylamino)-indane-2-carboxylic acid methyl ester → 2-{3-[2-(3-Hydroxy-phenyl)-ethoxy]-4-methoxy-benzoylamino}-indane-2-carboxylic acid

HRID 521512Notes

Reaction equation

HRID 521512 reaction equation
O[CH2:2][CH2:3][C:4]1[CH:5]=[C:6]([O:10]C(=O)C)[CH:7]=[CH:8][CH:9]=1.C[O:15][C:16]([C:18]1([NH:27][C:28](=[O:38])[C:29]2[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[C:31]([OH:37])[CH:30]=2)[CH2:26][C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH2:19]1)=[O:17]>>[OH:10][C:6]1[CH:5]=[C:4]([CH2:3][CH2:2][O:37][C:31]2[CH:30]=[C:29]([CH:34]=[CH:33][C:32]=2[O:35][CH3:36])[C:28]([NH:27][C:18]2([C:16]([OH:15])=[O:17])[CH2:19][C:20]3[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:26]2)=[O:38])[CH:9]=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 670765182-(3-Hydroxy-4-methoxy-benzoylamino)-indane-2-carboxylic acid methyl esterHCID 67076782Acetic acid 3-(2-hydroxy-ethyl)-phenyl ester

Product 1

HCID 670765812-{3-[2-(3-Hydroxy-phenyl)-ethoxy]-4-methoxy-benzoylamino}-indane-2-carboxylic acid

Procedure

The compound of step 1 and the compound of step 2 of example 15 were reacted in analogy to step 3 of example 15 and the obtained ester hydrolyzed in analogy to example 16.

Sources & evidence

ORD record
ord-81c2e1cc422d4aeb8b9b66343c3f5bec
Source dataset
uspto-grants-2016_05
Patent number
US09328071B2

Reaction notes

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