HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → Acetic acid 2-[3-(2-hydroxy-ethyl)-phenyl]-ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 2-[3-(2-Hydroxyethyl)phenyl]ethanol | HCID 10080741 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Acetic acid 2-[3-(2-hydroxy-ethyl)-phenyl]-ethyl ester | HCID 67076325 | 41.6% |
Reaction Steps
2-[3-(2-Hydroxy-ethyl)-phenyl]-ethanol (2.49 g, 15.0 mmol) was dissolved in ACN (5 ml) and acetic anhydride (3.06 g, 30 mmol) added. The mixture was stirred under reflux for 1 h and then evaporated to dryness. Silica gel chromatography (HEP/EA gradient) of the residue yielded 1.30 g of the title compound (mono-acetylated product).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09328071B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-0a04cf3d348c4d6f8e8f7199c4080f55 |
| Source note | uspto-grants-2016_05 |