HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methylbenzeneethanol → 2-[2-Fluoro-4-methoxy-3-(2-m-tolyl-ethoxy)-benzoylamino]-indane-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methylbenzeneethanol | HCID 74648 | — |
| Reactant | methyl 2-amino-2,3-dihydro-1H-indene-2-carboxylate hydrochloride | HCID 45074056 | — |
| Reactant | Methyl 2-fluoro-3-hydroxy-4-methoxybenzoate | HCID 67076493 | — |
| Product | 2-[2-Fluoro-4-methoxy-3-(2-m-tolyl-ethoxy)-benzoylamino]-indane-2-carboxylic acid | HCID 67076663 | — |
Reaction Steps
2-Fluoro-3-hydroxy-4-methoxybenzoic acid methyl ester was etherified with 2-m-tolyl-ethanol in analogy to step 1 of example 1, the obtained ester hydrolyzed in analogy to example 2, the obtained carboxylic acid reacted with 2-amino-indane-2-carboxylic acid methyl ester hydrochloride in analogy to step 3 of example 1, and the methyl ester hydrolyzed in analogy to example 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09328071B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-6265f2aa74b14de69652b681af5b5ee3 |
| Source note | uspto-grants-2016_05 |