反应详情

温度

100 °C

A mixture of 2-aminothiophenol (5.01 g, 40.0 mmol), 5-bromo-2-formylpyridine (7.44 g, 40.0 mmol) and ethanol (40 mL) was heated to reflux (100° C.) while open to the atmosphere for 3 days. Upon confirming consumption of the starting materials by TLC (SiO2, 29:1 hexanes-acetone), the reaction was cooled to RT, the resulting mixture filtered and the filtrant washed copiously with ethanol to afford 9 (5.62 g, 48% yield) as an off-white solid.

1. temperaturewas heated
2. customconsumption of the starting materials by TLC (SiO2, 29:1 hexanes-acetone)
3. temperaturethe reaction was cooled to RT
4. filtrationthe resulting mixture filtered
5. washthe filtrant washed copiously with ethanol