참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrazine | HCID 9321 | — |
| 반응물 | 3,6-Dichloropyridazine-4-carboxylic acid | HCID 433804 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 6-Chloro-3-hydrazinylpyridazine-4-carboxylic acid | HCID 20538578 | — |
반응 단계
To a solution of 3,6-dichloropyridazin-4-carboxylic acid (5 g, 26 mmol) in EtOH (200 mL) was added TEA (4 mL, 30 mmol) and hydrazine (5 mL, 80%). The reaction mixture was stirred at 85° C. for 3 hours. After cooled to room temperature, the mixture was concentrated in vacuum to give crude product 6-chloro-3-hydrazinylpyridazine-4-carboxylic acid (4.8 g), which was used for the next step directly without purification. LRMS (M+H+) m/z: calcd 189; found 189.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09328117B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_05 |
|---|
| ORD ID | ord-ff16b08230e344ea9e4dcd518a6c019e |
|---|
| 출처 메모 | uspto-grants-2016_05 |
|---|
