Hydrazine hydrate (1:1) → 3-Chloro-6-hydrazinopyridazine

Participants

Reaction Steps

A mixture of 3,6-dichloropyridazine (20 g, 0.135 mol) and 20 mL of 80% hydrazine hydrate in 40 mL of ethanol was refluxed for 1 h. The reaction mixture was evaporated to dryness and the residue was recrystallized from benzene to give 3-chloro-6-hydrazinylpyridazine as a yellow solid (19 g, 96%). LRMS (M+H+) m/z: calcd 145.03; found 145.

Provenance & Evidence