2-Amino-4-(trifluoromethyl)benzamide → 2-(2-ethylsulfanylphenyl)-7-trifluoromethyl-3H-quinazolin-4-one

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A mixture of 1.0 g of 2-amino-4-trifluromethylbenzamide, 813 mg of 2-ethylsulfanylbenzaldehyde, 764 mg of sodium bisulfite and 4 ml of DMA was stirred at 150° C. for 8 hours. A saturated aqueous sodium bicarbonate solution and water were added to the cooled reaction mixture, and the precipitated solid was filtered. The resulting solid was washed with water and n-hexane and then dried to obtain 1.49 g of 2-(2-ethylsulfanylphenyl)-7-trifluoromethyl-3H-quinazolin-4-one.

Herkunft & Nachweise