3-Bromo-1,1,1-trifluoro-2-propanone → 6-Bromo-5-methyl-2-trifluoromethyl-2,3-dihydroimidazo [1,2-a]pyridin-2-ol hydrobromide

Participants

Reaction Steps

A mixture of 1.91 g of 3-bromo-1,1,1-trifluoropropan-2-one and 10 ml of DME was added to a mixture of 1.87 g of 2-amino-5-bromo-6-methylpyridine and 10 ml of DME, and the mixture was stirred at room temperature for 3 hours. The precipitated solid was taken by filtration, washed with 10 ml of DME, and dried to obtain 3.39 g of 6-bromo-5-methyl-2-trifluoromethyl-2,3-dihydroimidazo [1,2-a]pyridin-2-ol hydrobromide.

Provenance & Evidence