反应详情

A mixture of 3.29 g of 6-bromo-5-methyl-2-trifluoromethyl-2,3-dihydroimidazo[1,2-a]pyridin-2-ol hydrobromide and 10 ml of ethanol was stirred under heat-reflux for 3 hours. The cooled reaction mixture was concentrated under reduced pressure, then water was added, and the mixture was extracted with ethyl acetate. The mixture was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain 2.72 g of 6-bromo-5-methyl-2-trifluoromethylimidazo[1,2-a]pyridine.

1. temperatureunder heat-reflux for 3 hours
2. customThe cooled reaction mixture
3. concentrationwas concentrated under reduced pressure
4. additionwater was added
5. extractionthe mixture was extracted with ethyl acetate
6. dry with materialThe mixture was dried over anhydrous sodium sulfate
7. concentrationconcentrated under reduced pressure