6-Bromo-5-methyl-2-pentafluoroethyl-2,3-dihydroimidazo[1,2-a]pyridin-2-ol hydrobromide → 6-Bromo-5-methyl-2-pentafluoroethylimidazo[1,2-a]pyridine

Participants

Reaction Steps

A mixture of 3.95 g of 6-bromo-5-methyl-2-pentafluoroethyl-2,3-dihydroimidazo[1,2-a]pyridin-2-ol hydrobromide and 20 ml of ethanol was stirred under heat-reflux for 1 day. The cooled reaction mixture was concentrated under reduced pressure, then water and a saturated aqueous sodium bicarbonate solution were added, and the precipitated solid was taken by filtration. The resulting solid was dried to obtain 2.92 g of 6-bromo-5-methyl-2-pentafluoroethylimidazo[1,2-a]pyridine.

Provenance & Evidence