HCID 118035057, compound → HCID 91667369, compound

HRID 521693Notes

Reaction equation

HRID 521693 reaction equation
Br.[Br:2][C:3]1[CH:4]=[N:5][C:6]2[N:7]([CH2:9][C:10]([C:13]([F:16])([F:15])[F:14])(O)[N:11]=2)[CH:8]=1>C(O)C>[Br:2][C:3]1[CH:4]=[N:5][C:6]2[N:7]([CH:9]=[C:10]([C:13]([F:16])([F:15])[F:14])[N:11]=2)[CH:8]=1

Participants

3

Reactant 1

HCID 118035057HCID 118035057, compound

Product 1

HCID 91667369HCID 91667369, compoundYield 76.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 0.97 g of resulting 6-bromo-2-trifluoromethyl-2,3-dihydroimidazo[1,2-a]pyrimidin-2-ol hydrobromide and 10 ml of ethanol was stirred under heat-reflux for 5 hours. The cooled reaction mixture was concentrated under reduced pressure, then water was added, and the mixture was extracted with ethyl acetate. The resulting matter was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 0.54 g of 6-bromo-2-trifluoromethyl-imidazo[1,2-a]pyrimidine.

Workup

  1. temperatureunder heat-reflux for 5 hours
  2. customThe cooled reaction mixture
  3. concentrationwas concentrated under reduced pressure
  4. additionwater was added
  5. extractionthe mixture was extracted with ethyl acetate
  6. dry with materialThe resulting matter was dried over anhydrous sodium sulfate
  7. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-233c94f1aa174d50ba8e73fbae710f05
Source dataset
uspto-grants-2016_05
Patent number
US09328121B1

Reaction notes

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