HCID 137199430, compound → HCID 90111971, compound

Participants

Reaction Steps

A solution of tert-butyl N-allyl-N-(2-hydroxyimino-2-pyrazin-2-yl-ethyl)carbamate (6.6 g, 22.58 mmol) in toluene (80 mL) is stirred at 120° C. for 22 hours. The reaction is cooled and the solvent is evaporated under reduced pressure. The crude product is purified by silica gel column chromatography using a 0-5% gradient of 0.14 M ammonia/methanol solution in dichloromethane to give the title compound (5.13 g, 74%). ES/MS (m/e): 293 (M+1).

Provenance & Evidence