Trifluoroacetic acid → HCID 90112413, compound

Participants

Reaction Steps

To a solution of tert-butyl 1-[(4-methoxyphenyl)methyl]-6a-(4-pyridyl)-3,3a,4,6-tetrahydropyrrolo[3,4-c]isoxazole-5-carboxylate (1.3 g, 3.16 mmol) in dichloromethane (30 mL) is added trifluoroacetic acid (7 mL, 94.77 mmol). The resulting solution is stirred at room temperature for 1 hour. The reaction is concentrated and the resulting residue is kept at room temperature overnight. This residue is then loaded onto an ion exchange column and the column is first eluted with methanol followed by 2 M ammonia/methanol solution. The desired basic fraction is collected and concentrated under reduced pressure to give the title compound (592 mg, 98%). ES/MS (m/e): 192 (M+1).

Provenance & Evidence