Benzoyl isothiocyanate → HCID 90111324, compound

Participants

Reaction Steps

To a stirred solution of [4-amino-1-(5-fluoro-4-methoxy-6-methyl-pyrimidin-2-yl)-4-pyrazin-2-yl-pyrrolidin-3-yl]methanol (930 mg, 2.78 mmol) in tetrahydrofuran (29 mL) under a nitrogen atmosphere is added benzoyl isothiocyanate (613 μL, 4.45 mmol). After stirring the reaction at room temperature for 1 hour the solvent is removed under reduced pressure. The resulting residue is purified by silica gel column chromatography using a 0-5% gradient of 0.14 M ammonia/methanol solution in dichloromethane to give the title compound (1.32 g, 95%). ES/MS (m/e): 498 (M+1).

Provenance & Evidence