Trifluoroacetic acid → HCID 90110162, compound

Participants

Reaction Steps

Trifluoroacetic acid (1.5 mL) is added to a stirred solution of tert-butyl(4aR,7aR)-2-benzamido-7a-pyrazin-2-yl-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazine-6-carboxylate (299 mg, 0.680 mmol) in dichloromethane (6 mL) at room temperature. The reaction is stirred at room temperature for 80 minutes and the solvent is evaporated under reduced pressure. The resulting residue is dissolved in methanol (20 mL) and this solution is loaded onto an ion exchange column and eluted with methanol then with 7 M ammonia/methanol solution. The basic fraction is collected and concentrated under reduced pressure to give the title compound (231 mg, quantitative). ES/MS (m/e): 340 (M+1).

Provenance & Evidence