Methanol → HCID 90121193, compound

Participants

Reaction Steps

Racemic 6-(5-fluoro-4-methoxy-6-methyl-pyrimidin-2-yl)-7a-pyrazin-2-yl-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-2-amine (490 mg, 1.3 mmol) is separated into its constituent enantiomers by chiral SFC (Column: Chiralcel OD-H (5μ), 21.2×250 mm; eluent: 50% methanol (0.2% diethylmethylamine) in CO2; flow: 70 mL/min at UV 260 nm). The first eluting isomer is the title compound (206 mg, 32%). ES/MS (m/e): 376 (M+1).

Provenance & Evidence