Methanol → HCID 90121188, compound

Participants

Reaction Steps

Racemic 6-(5-fluoro-4-isopropyl-pyrimidin-2-yl)-7a-(3-pyridyl)-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-2-amine (210 mg, 0.564 mmol) is separated into its constituent enantiomers by chiral SFC (Column: Chiralcel OD-H (5μ), 21.2×250 mm; eluent: 25% methanol (0.2% diethylmethylamine) in CO2; flow: 70 mL/min at UV 260 nm). The first eluting isomer is further purified again by chiral SFC (Column: Chiralcel OD-H (5μ), 21.2×250 mm; eluent: 15% methanol (0.2% diethylmethylamine) in CO2; flow: 70 mL/min at UV 260 nm) to obtain the title compound (71 mg). ES/MS (m/e): 373 (M+1).

Provenance & Evidence