Ethanol → HCID 90121166, compound

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Reaction Steps

Racemic 6-(5-fluoro-4-isopropyl-pyrimidin-2-yl)-7a-pyrazin-2-yl-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-2-amine (127 mg, 0.340 mmol) is separated into its constituent enantiomers by chiral SFC (Column: Chiralcel OD-H (5μ), 21.2×250 mm; eluent: 50% ethanol (0.2% diethylmethylamine) in CO2; flow: 70 mL/min at UV 260 nm). The first eluting isomer is the title compound (54 mg). ES/MS (m/e): 374 (M+1).

Provenance & Evidence