Ethanol → HCID 90121207, compound

Participants

Reaction Steps

Racemic 6-(5-fluoropyrimidin-2-yl)-7a-(4-pyridyl)-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-2-amine (185 mg, 0.56 mmol) is separated into its constituent enantiomers by chiral SFC (Column: Chiralcel OJ-H (5μ), 21.2×250 mm; eluent: 25% ethanol (0.2% diethylmethylamine) in CO2; flow: 70 mL/min at UV 260 nm). The second eluting isomer is the title compound (40 mg). ES/MS (m/e): 331 (M+1).

Provenance & Evidence