2-Bromo-5-(4-fluorobenzyl)thiophene → HCID 10730059, compound

HRID 52174Notes

Reaction equation

HRID 52174 reaction equation
Br[C:2]1[S:3][C:4]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[CH:5][CH:6]=1.BrC1[O:17][C:18]([CH2:21]C2C=CC(F)=CC=2)=[CH:19][CH:20]=1>>[F:14][C:11]1[CH:12]=[CH:13][C:8]([CH2:7][C:4]2[S:3][C:2]([C:20]#[C:19][CH:18]([OH:17])[CH3:21])=[CH:6][CH:5]=2)=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 105400132-Bromo-5-(4-fluorobenzyl)thiopheneHCID 199632922-Bromo-5-[(4-fluorophenyl)methyl]furan

Product 1

HCID 10730059HCID 10730059, compoundYield 71%

Procedure

4-[5-(4-fluorophenylmethyl)-2-thienyl]-3-butyn-2-ol (9.16 g, 71%) was prepared according to the method of Example 1, step 3, except substituting 2-bromo-5-(4-fluorophenylmethyl)thiophene (13.3 g, 49.0 mmol), prepared as in step 2, for 2-bromo-5-(4-fluorophenylmethyl)furan.

Sources & evidence

ORD record
ord-7f442a239bb94dbb92653007547e88da
Source dataset
uspto-grants-1997_04
Patent number
US05616596

Reaction notes

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