(2-Fluoro-4-methoxyphenyl)boronic acid → 2-(2-Fluoro-4-methoxyphenyl)-1,3-thiazole-4-carboxylic acid

HRID 521895Notes

Reaction equation

HRID 521895 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[C:4](F)[C:3]=1[C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1.FC1C=C(OC)C=CC=1B(O)O>>[F:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1

Participants

3

Reactant 2

HCID 15789384(2-Fluoro-4-methoxyphenyl)boronic acidHCID 834100432-(2,6-Difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid

Product 1

HCID 460655832-(2-Fluoro-4-methoxyphenyl)-1,3-thiazole-4-carboxylic acid

Procedure

Following the procedure of Intermediate 104, replacing 2,6-difluoro-4-methoxyphenylboronic acid with 2-fluoro-4-methoxyphenylboronic acid gave the title compound.

Sources & evidence

ORD record
ord-eb016079390d43088a91cef75eaeae22
Source dataset
uspto-grants-2016_05
Patent number
US09328106B2

Reaction notes

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