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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 521899Generated: October 26, 2026

2-(2,6-Difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid → 2-(2,6-Difluoro-4-(1-hydroxyethyl)phenyl)thiazole-4-carboxylic acid

https://huagongshe.com/reaction/521899

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(2,6-Difluoro-4-methoxyphenyl)thiazole-4-carboxylic acidHCID 83410043—
Reactant1-(3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanolHCID 86713851—
Product2-(2,6-Difluoro-4-(1-hydroxyethyl)phenyl)thiazole-4-carboxylic acidHCID 86713852—

Reaction Steps

Following the procedure of Intermediate 104, replacing 2,6-difluoro-4-methoxyphenylboronic acid with 1-(3,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanol (Intermediate 106) gave the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09328106B2
Source datasetuspto-grants-2016_05
ORD IDord-2f591240fbad4dc99f044823cdb1efda
Source noteuspto-grants-2016_05