HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutanol → 2-(2,6-Difluoro-4-(1-hydroxycyclobutyl)phenyl)thiazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutanol | HCID 70655110 | — |
| Reactant | 2-(2,6-Difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid | HCID 83410043 | — |
| Product | 2-(2,6-Difluoro-4-(1-hydroxycyclobutyl)phenyl)thiazole-4-carboxylic acid | HCID 86713853 | — |
Reaction Steps
Following the procedure of Intermediate 104, replacing 2,6-difluoro-4-methoxyphenylboronic acid with 1-(3,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutanol (Intermediate 108) gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09328106B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-2eed32902ace4c9c8984cd38458335b5 |
| Source note | uspto-grants-2016_05 |