(5-Chloro-2-fluoro-phenyl)boronic acid → 2-(5-Chloro-2-fluorophenyl)thiazole-4-carboxylic acid

HRID 521904Notes

Reaction equation

HRID 521904 reaction equation
[F:1][C:2]1[CH:7]=[C:6](OC)[CH:5]=[C:4](F)[C:3]=1[C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1.[Cl:19]C1C=CC(F)=C(B(O)O)C=1>>[Cl:19][C:5]1[CH:6]=[CH:7][C:2]([F:1])=[C:3]([C:11]2[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=2)[CH:4]=1

Participants

3

Reactant 2

HCID 3718925(5-Chloro-2-fluoro-phenyl)boronic acidHCID 834100432-(2,6-Difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid

Product 1

HCID 624945822-(5-Chloro-2-fluorophenyl)thiazole-4-carboxylic acid

Procedure

Following the procedure of Intermediate 104, replacing 2,6-difluoro-4-methoxyphenylboronic acid with (5-chloro-2-fluorophenyl)boronic acid gave the title compound.

Sources & evidence

ORD record
ord-82905cab88814e0e98c0a759d032e33e
Source dataset
uspto-grants-2016_05
Patent number
US09328106B2

Reaction notes

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