Boronic acid, B-(2,6-difluoro-3-methylphenyl)- → HCID 67500322, compound

HRID 521905Notes

Reaction equation

HRID 521905 reaction equation
[F:1][C:2]1[CH:7]=[C:6](OC)[CH:5]=[C:4]([F:10])[C:3]=1[C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1.F[C:20]1C(C)=CC=C(F)C=1B(O)O>>[F:1][C:2]1[C:7]([CH3:20])=[CH:6][CH:5]=[C:4]([F:10])[C:3]=1[C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1

Participants

3

Reactant 2

HCID 16427092Boronic acid, B-(2,6-difluoro-3-methylphenyl)-HCID 834100432-(2,6-Difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid

Product 1

HCID 67500322HCID 67500322, compound

Procedure

Following the procedure of Intermediate 104, replacing 2,6-difluoro-4-methoxyphenylboronic acid with (2,6-difluoro-3-methylphenyl)boronic acid gave the title compound.

Sources & evidence

ORD record
ord-840ed624d60d4e3785eeabe2132eb0fa
Source dataset
uspto-grants-2016_05
Patent number
US09328106B2

Reaction notes

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