HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3,5-Difluorophenyl)ethan-1-ol → (S)-2-(2,6-difluoro-4-(1-hydroxyethyl)phenyl)thiazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3,5-Difluorophenyl)ethan-1-ol | HCID 2782326 | — |
| Reactant | (S)-1-(3,5-difluorophenyl)ethanol | HCID 40786925 | — |
| Reactant | 1-(3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanol | HCID 86713851 | — |
| Reactant | 2-(2,6-Difluoro-4-(1-hydroxyethyl)phenyl)thiazole-4-carboxylic acid | HCID 86713852 | — |
| Product | (S)-2-(2,6-difluoro-4-(1-hydroxyethyl)phenyl)thiazole-4-carboxylic acid | HCID 86713857 | — |
Reaction Steps
Following the procedure of Intermediate 109, replacing 1-(3,5-difluorophenyl)ethanol in step 1 (Intermediate 106) with (S)-1-(3,5-difluorophenyl)ethanol (commercial source).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09328106B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-b918590eba4e4d699d1d61101af089b7 |
| Source note | uspto-grants-2016_05 |