(5-Ethyl-2-fluorophenyl)boronic acid → 2-(5-Ethyl-2-fluorophenyl)thiazole-4-carboxylic acid

HRID 521909Notes

Reaction equation

HRID 521909 reaction equation
F[C:2]1[CH:7]=[C:6](OC)[CH:5]=[C:4]([F:10])[C:3]=1[C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1.[CH2:19](C1C=CC(F)=C(B(O)O)C=1)[CH3:20]>>[CH2:19]([C:7]1[CH:6]=[CH:5][C:4]([F:10])=[C:3]([C:11]2[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=2)[CH:2]=1)[CH3:20]

Participants

3

Reactant 2

HCID 53216556(5-Ethyl-2-fluorophenyl)boronic acidHCID 834100432-(2,6-Difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid

Product 1

HCID 867138592-(5-Ethyl-2-fluorophenyl)thiazole-4-carboxylic acid

Procedure

Following the procedure of Intermediate 104, replacing 2,6-difluoro-4-methoxyphenylboronic acid with (5-ethyl-2-fluorophenyl)boronic acid gave the title compound.

Sources & evidence

ORD record
ord-78e436c69b304415be1d86ff51ea3a08
Source dataset
uspto-grants-2016_05
Patent number
US09328106B2

Reaction notes

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