HCID 66521482, compound → HCID 86713860, compound

HRID 521912Notes

Reaction equation

HRID 521912 reaction equation
F[C:2]1[CH:7]=[C:6](OC)[CH:5]=[C:4]([F:10])[C:3]=1[C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1.[CH:19]1(C2C=CC(F)=C(B(O)O)C=2)[CH2:21][CH2:20]1>>[CH:19]1([C:7]2[CH:6]=[CH:5][C:4]([F:10])=[C:3]([C:11]3[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=3)[CH:2]=2)[CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 66521482HCID 66521482, compoundHCID 834100432-(2,6-Difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid

Product 1

HCID 86713860HCID 86713860, compound

Procedure

Following the procedure of Intermediate 104, replacing 2,6-difluoro-4-methoxyphenylboronic acid with (5-cyclopropyl-2-fluorophenyl)boronic acid gave the title compound.

Sources & evidence

ORD record
ord-340f2ed2bceb416cbdc60038becc0c73
Source dataset
uspto-grants-2016_05
Patent number
US09328106B2

Reaction notes

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