(4-Chloro-2-fluorophenyl)boronic acid → HCID 63082765, compound

HRID 521916Notes

Reaction equation

HRID 521916 reaction equation
[F:1][C:2]1[CH:7]=[C:6](OC)[CH:5]=[C:4](F)[C:3]=1[C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1.[Cl:19]C1C=CC(B(O)O)=C(F)C=1>>[Cl:19][C:6]1[CH:5]=[CH:4][C:3]([C:11]2[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=2)=[C:2]([F:1])[CH:7]=1

Participants

3

Reactant 2

HCID 4193595(4-Chloro-2-fluorophenyl)boronic acidHCID 834100432-(2,6-Difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid

Product 1

HCID 63082765HCID 63082765, compound

Procedure

Following the procedure of Intermediate 104, replacing 2,6-difluoro-4-methoxyphenylboronic acid with (4-chloro-2-fluorophenyl)boronic acid gave the title compound.

Sources & evidence

ORD record
ord-644b468dbbec4b22a0402281c450d5c3
Source dataset
uspto-grants-2016_05
Patent number
US09328106B2

Reaction notes

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