(2-Fluoro-6-methylphenyl)boronic acid → 2-(2-Fluoro-6-methylphenyl)thiazole-4-carboxylic acid

HRID 521917Notes

Reaction equation

HRID 521917 reaction equation
F[C:2]1[CH:7]=[C:6](OC)[CH:5]=[C:4]([F:10])[C:3]=1[C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1.F[C:20]1C=CC=C(C)C=1B(O)O>>[F:10][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([CH3:20])[C:3]=1[C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1

Participants

3

Reactant 2

HCID 54758890(2-Fluoro-6-methylphenyl)boronic acidHCID 834100432-(2,6-Difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid

Product 1

HCID 867138622-(2-Fluoro-6-methylphenyl)thiazole-4-carboxylic acid

Procedure

Following the procedure of Intermediate 104, replacing 2,6-difluoro-4-methoxyphenylboronic acid with (2-fluoro-6-methylphenyl)boronic acid gave the title compound.

Sources & evidence

ORD record
ord-41dcad7c6555427697618dca1f3e013d
Source dataset
uspto-grants-2016_05
Patent number
US09328106B2

Reaction notes

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