HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 521919Generated: October 30, 2026
Ethyl bromopyruvate → Ethyl 2-(5-bromo-2-fluoro-phenyl)thiazole-4-carboxylate
https://huagongshe.com/reaction/521919
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl bromopyruvate | HCID 66144 | — |
| Reactant | 5-Bromo-2-fluorobenzene-1-carbothioamide | HCID 82647922 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 2-(5-bromo-2-fluoro-phenyl)thiazole-4-carboxylate | HCID 86713863 | 76.14% |
Reaction Steps
A mixture of 5-bromo-2-fluoro-benzenecarbothioamide (11.8 mmol, 2840 mg) and ethyl bromopyruvate (1.05 equiv., 12.4 mmol, 1.56 mL) in ethanol (30 mL) was heated at 80° C. overnight. The mixture was concentrated and the residue was purified on silica eluted with 0 to 20% EtOAc in Heptane to afford ethyl 2-(5-bromo-2-fluoro-phenyl)thiazole-4-carboxylate (2960 mg, 76.14% Yield) as a clear oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09328106B2 |
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| Source dataset | uspto-grants-2016_05 |
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| ORD ID | ord-f2e99a77ae9a42b4ac7ce163951d8682 |
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| Source note | uspto-grants-2016_05 |
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