HRID521923

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID46311204

Methyl 6-bromo-5-fluoropyridine-2-carboxylate

C7H5BrFNO2

结构：CC(C)(O)c1cc(F)c(B2OC(C)(C)C(C)(C)O2)c(F)c1

HCID70655156

未命名化合物

2 次

HCID83410043

未命名化合物

PRODUCTS

生成物

结构：CC(C)(O)c1cc(F)c(-c2nc(C(=O)O)ccc2F)c(F)c1

HCID66652443

未命名化合物

PROCEDURE

实验过程

Following the procedure of Intermediate 104, replacing 2,6-difluoro-4-methoxyphenylboronic acid with 2-(3,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-ol (Intermediate 107) and replacing methyl 2-bromothiazole-4-carboxylate with methyl 6-bromo-5-fluoropicolinate (see US2012/225062) gave the title compound.