HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 6-bromo-5-fluoropyridine-2-carboxylate → 6-(2,6-Difluoro-4-(1-hydroxycyclobutyl)phenyl)-5-fluoropicolinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 6-bromo-5-fluoropyridine-2-carboxylate | HCID 46311204 | — |
| Reactant | 1-(3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutanol | HCID 70655110 | — |
| Reactant | 2-(2,6-Difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid | HCID 83410043 | — |
| Product | 6-(2,6-Difluoro-4-(1-hydroxycyclobutyl)phenyl)-5-fluoropicolinic acid | HCID 70655422 | — |
Reaction Steps
Following the procedure of Intermediate 104, replacing 2,6-difluoro-4-methoxyphenylboronic acid with 1-(3,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutanol (Intermediate 108) and replacing methyl 2-bromothiazole-4-carboxylate with methyl 6-bromo-5-fluoropicolinate (see US2012/225062) gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09328106B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-efd66030fc7840e58df1e43db015aa0f |
| Source note | uspto-grants-2016_05 |