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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 521925Generated: October 26, 2026

Methyl 6-bromo-5-fluoropyridine-2-carboxylate → HCID 86713865, compound

https://huagongshe.com/reaction/521925

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 6-bromo-5-fluoropyridine-2-carboxylateHCID 46311204—
Reactant2-(2,6-Difluoro-4-methoxyphenyl)thiazole-4-carboxylic acidHCID 83410043—
Reactant1-(3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanolHCID 86713851—
ProductHCID 86713865HCID 86713865—

Reaction Steps

Following the procedure of Intermediate 104, replacing 2,6-difluoro-4-methoxyphenylboronic acid with 1-(3,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanol (Intermediate 106) and replacing methyl 2-bromothiazole-4-carboxylate with methyl 6-bromo-5-fluoropicolinate (see US2012/225062) gave the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09328106B2
Source datasetuspto-grants-2016_05
ORD IDord-828d53d4ba074e86b5ae52ef90989a03
Source noteuspto-grants-2016_05