2,6-Difluoro-4-hydroxybenzeneboronic acid → 6-(2,6-Difluoro-4-hydroxyphenyl)-5-fluoropicolinic acid

HRID 521926Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 521926
[F:1][C:2]1[CH:7]=[C:6]([O:8]C)[CH:5]=[C:4]([F:10])[C:3]=1[C:11]1S[CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1.[F:19][C:20]1C=C(O)C=C(F)[C:21]=1B(O)O.BrC1N=C(C(OC)=O)C=CC=1F>>[F:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[C:4]([F:10])[C:3]=1[C:11]1[N:15]=[C:14]([C:16]([OH:18])=[O:17])[CH:13]=[CH:21][C:20]=1[F:19]

Komponenten

4

Edukt 3

HCID 459336202,6-Difluoro-4-hydroxybenzeneboronic acidHCID 46311204Methyl 6-bromo-5-fluoropyridine-2-carboxylateHCID 834100432-(2,6-Difluoro-4-methoxyphenyl)thiazole-4-carboxylic acid

Produkt 1

HCID 1363772296-(2,6-Difluoro-4-hydroxyphenyl)-5-fluoropicolinic acid

Versuchsvorschrift

Following the procedure of Intermediate 104, replacing 2,6-difluoro-4-methoxyphenylboronic acid with (2,6-difluoro-4-hydroxyphenyl)boronic acid and replacing methyl 2-bromothiazole-4-carboxylate with methyl 6-bromo-5-fluoropicolinate (see US2012/225062) gave the title compound.

Quellen und Nachweise

ORD-Eintrag
ord-2edba2e5524b40dcbd87dd20cf29e5fc
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09328106B2

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