HCID 62790817, compound → HCID 86713869, compound

HRID 521930Notes

Reaction equation

HRID 521930 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:18]([OH:20])[CH3:19])[CH:5]=[C:6]([F:17])[C:7]=1[B:8]1[O:12][C:11]([CH3:14])([CH3:13])[C:10]([CH3:16])([CH3:15])[O:9]1.[CH:21]1(C(C2C=C(F)C=C(F)C=2)O)C[CH2:22]1>>[CH:19]1([CH:18]([C:4]2[CH:3]=[C:2]([F:1])[C:7]([B:8]3[O:12][C:11]([CH3:13])([CH3:14])[C:10]([CH3:15])([CH3:16])[O:9]3)=[C:6]([F:17])[CH:5]=2)[OH:20])[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 62790817HCID 62790817, compound2×HCID 867138511-(3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanol

Product 1

HCID 86713869HCID 86713869, compound

Procedure

Following the procedure of Intermediate 106, replacing 1-(3,5-difluorophenyl)ethanol with cyclopropyl(3,5-difluorophenyl)methanol (Intermediate 139) provided the title compound.

Sources & evidence

ORD record
ord-1fae1e7b95774000b991ed4131b90040
Source dataset
uspto-grants-2016_05
Patent number
US09328106B2

Reaction notes

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