1-(3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanol → HCID 70655139, compound

HRID 521932Notes

Reaction equation

HRID 521932 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:18]([OH:20])[CH3:19])[CH:5]=[C:6]([F:17])[C:7]=1[B:8]1[O:12][C:11]([CH3:14])([CH3:13])[C:10]([CH3:16])([CH3:15])[O:9]1.CO.FC1C=C([C:31]2(O)CC[O:33][CH2:32]2)C=C(F)C=1>>[F:17][C:6]1[CH:5]=[C:4]([C:18]2([OH:20])[CH2:31][CH2:32][O:33][CH2:19]2)[CH:3]=[C:2]([F:1])[C:7]=1[B:8]1[O:12][C:11]([CH3:13])([CH3:14])[C:10]([CH3:15])([CH3:16])[O:9]1

Participants

3

Reactant 2

HCID 867138511-(3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanolHCID 86713870HCID 86713870, compound2×

Product 1

HCID 70655139HCID 70655139, compound

Procedure

Following the procedure of Intermediate 106, replacing 1-(3,5-difluorophenyl)ethanol with 3-(3,5-difluorophenyl)tetrahydrofuran-3-ol methanol (Intermediate 142) provided the title compound.

Sources & evidence

ORD record
ord-0dfcabfc4c8e455cb40b4b32fa8b1a74
Source dataset
uspto-grants-2016_05
Patent number
US09328106B2

Reaction notes

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