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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 521938Generated: October 27, 2026

(S)-(+)-3-Hydroxytetrahydrofuran → (S)-2-(2,6-difluoro-4-((tetrahydrofuran-3-yl)oxy)phenyl)thiazole-4-carboxylic acid

https://huagongshe.com/reaction/521938

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(S)-(+)-3-HydroxytetrahydrofuranHCID 2733227—
Reactant(R)-2-(2,6-difluoro-4-((tetrahydrofuran-3-yl)oxy)phenyl)thiazole-4-carboxylic acidHCID 86713875—
Product(S)-2-(2,6-difluoro-4-((tetrahydrofuran-3-yl)oxy)phenyl)thiazole-4-carboxylic acidHCID 86713876—

Reaction Steps

Following the procedure for Intermediate 147, replacing (R)-3-hydroxytetrahydrofuran with (S)-3-hydroxytetrahydrofuran provided the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09328106B2
Source datasetuspto-grants-2016_05
ORD IDord-bad77950b99e4699a27bb71205e24d23
Source noteuspto-grants-2016_05