反应详情

To a solution of (Z)-5-(1-fluorocyclohept-4-enyl)-1-methyl-4-nitro-1H-pyrazole (900 mg, 3.77 mmol) in DCM (30 mL) at 0° C. was added portionwise meta-chloroperoxybenzoic acid (1.0 g, 4.14 mmol). The reaction mixture was allowed to warm to room temperature and stirred for 90 min before being quenched with a saturated solution of sodium hydrogencarbonate (30 mL). The mixture was extracted with DCM (100 mL), washed with aqueous 2 M NaOH (2×50 mL) and brine (30 mL). The organic layer was separated, dried over MgSO4 and concentrated under reduced pressure to give 5-(4-fluoro-8-oxabicyclo[5.1.0]octan-4-yl)-1-methyl-4-nitro-1H-pyrazole as a colourless solid (982 mg, quantitative) as a 2:5 ratio of diastereomers.

1. custombefore being quenched with a saturated solution of sodium hydrogencarbonate (30 mL)
2. extractionThe mixture was extracted with DCM (100 mL)
3. washwashed with aqueous 2 M NaOH (2×50 mL) and brine (30 mL)
4. customThe organic layer was separated
5. dry with materialdried over MgSO4
6. concentrationconcentrated under reduced pressure