HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluidine → 1H-Pyrrolizin-1-one, 2,3-dihydro-2-[[(4-methylphenyl)amino]methyl]-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluidine | HCID 7813 | — |
| Reactant | 2-Dimethylaminomethyl-1, 2-dihydro-1-pyrrolizinone | HCID 10219668 | — |
| Product | 1H-Pyrrolizin-1-one, 2,3-dihydro-2-[[(4-methylphenyl)amino]methyl]- | HCID 11776437 | 83% |
Reaction Steps
A solution of 17.5 g, compound (2) and 10 g 4-methylaniline was allowed to stand at room temperature for 12 hours. 22 g yellow solid was obtained after filtering. Recrystallized from ethanol, 19 g (5) was obtained as a white crystal, mp 112°-114° C., yield 83%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05616604 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-21fd8035906d4459b94e4244a6df8a84 |
| Source note | uspto-grants-1997_04 |