HRID521996

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(O)Cn1cc(B2OC(C)(C)C(C)(C)O2)cn1

HCID58204131

2-methyl-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propan-2-ol

C13H23BN2O3

结构：Cn1ncc(NC(=O)c2csc(Br)n2)c1[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)[C@H](F)CO1

HCID86713845

未命名化合物

2 次

PRODUCTS

生成物

结构：Cn1ncc(NC(=O)c2csc(-c3cnn(CC(C)(C)O)c3)n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1

HCID73438466

未命名化合物

PROCEDURE

实验过程

Following the procedure for Example 101 starting from tert-butyl ((3S,4R,7S)-7-(4-(2-bromothiazole-4-carboxamido)-1-methyl-1H-pyrazol-5-yl)-3-fluorooxepan-4-yl)carbamate (Intermediate 99), and replacing 3,6-dihydro-2H-pyran-4-boronic acid pinacol ester with 2-methyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propan-2-ol (see US2011/76291) gave 228. 1H NMR (400 MHz, DMSO-d6) δ 9.77 (s, 1H), 8.32 (s, 1H), 8.22 (s, 1H), 8.04 (s, 1H), 7.88 (s, 1H), 4.88 (dd, J=10.0, 3.9 Hz, 1H), 4.69-4.42 (m, 1H), 4.39-4.24 (m, 1H), 4.17-3.95 (m, 4H), 3.77 (s, 3H), 2.15-2.05 (m, 1H), 1.89-1.68 (m, 3H), 1.10 (d, J=4.4 Hz, 6H). LCMS (ES+) m/z 478 (M+1).