3,5-Dimethylisoxazole-4-boronic acid → N-(5-((2S,5R,6R)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-2-(3,5-dimethylisoxazol-4-yl)thiazole-4-carboxamide

Participants

Reaction Steps

Following the procedure for Example 101 starting from tert-butyl ((3R,4R,7S)-7-(4-(2-bromothiazole-4-carboxamido)-1-methyl-1H-pyrazol-5-yl)-3-fluorooxepan-4-yl)carbamate (Intermediate 100), and replacing 3,6-dihydro-2H-pyran-4-boronic acid pinacol ester with (3,5-dimethylisoxazol-4-yl)boronic acid gave 244. 1H NMR (400 MHz, DMSO-d6) δ 9.63 (s, 1H), 8.47 (s, 1H), 7.83 (s, 1H), 5.01 (d, J=50.4 Hz, 1H), 4.84 (d, J=10.2 Hz, 1H), 4.24-4.06 (m, 1H), 4.06-3.88 (m, 1H), 3.78 (s, 3H), 3.45-3.31 (m, 1H), 2.77 (s, 3H), 2.56 (s, 3H), 2.09-1.84 (m, 3H), 1.76-1.68 (m, 1H). LCMS (ES+) m/z 435 (M+1).

Provenance & Evidence