HCID 69812052, compound → HCID 86713937, compound

Participants

Reaction Steps

Following the procedure for Example 111 starting from tert-butyl ((3S,4R,7S)-3-fluoro-7-(1-methyl-4-nitro-1H-pyrazol-5-yl)oxepan-4-yl)carbamate (Intermediate 80), and replacing 5-((tert-butoxycarbonyl)amino)-2-(2,6-difluorophenyl)thiazole-4-carboxylic acid with 5-((tert-butoxycarbonyl)amino)-2-(5-chloro-2-fluorophenyl)thiazole-4-carboxylic acid (Intermediate 132) gave 291. 1H NMR (400 MHz, DMSO-d6) δ 9.41 (s, 1H), 8.29 (dd, J=6.5, 2.7 Hz, 1H), 7.73 (bs, 1H), 7.51 (s, 2H), 7.48-7.36 (m, 2H), 7.08-6.53 (m, 1H), 4.85 (dd, J=9.9, 4.1 Hz, 1H), 4.51-4.31 (m, 1H), 4.29-3.93 (m, 2H), 3.78 (s, 3H), 2.18-2.07 (m, 1H), 1.93-1.79 (m, 1H), 1.78-1.62 (m, 3H). LCMS (ES+) m/z 483 (M+1).

Provenance & Evidence