tert-butyl ((3S,4R,7S)-3-fluoro-7-(1-methyl-4-nitro-1H-pyrazol-5-yl)oxepan-4-yl)carbamate → HCID 86713943, compound

Participants

Reaction Steps

Following the procedure for Example 111 starting from tert-butyl ((3S,4R,7S)-3-fluoro-7-(1-methyl-4-nitro-1H-pyrazol-5-yl)oxepan-4-yl)carbamate (Intermediate 80), and replacing 5-((tert-butoxycarbonyl)amino)-2-(2,6-difluorophenyl)thiazole-4-carboxylic acid with 2-(2-fluoro-4-methylphenyl)thiazole-4-carboxylic acid (Intermediate 131) gave 316. 1H NMR (400 MHz, DMSO-d6) δ 9.87 (s, 1H), 8.48 (s, 1H), 8.36 (t, J=8.1 Hz, 1H), 7.89 (s, 1H), 7.34-7.18 (m, 2H), 4.87 (dd, J=10.6, 3.6 Hz, 1H), 4.57-4.39 (m, 1H), 4.38-4.25 (m, 1H), 4.19-4.01 (m, 1H), 3.78 (s, 3H), 2.40 (s, 3H), 2.12-2.03 (m, 1H), 1.88-1.78 (m, 1H), 1.77-1.66 (m, 3H). LCMS (ES+) m/z 448 (M+1).

Provenance & Evidence