HCID 58465104, compound → HCID 86713948, compound

Participants

Reaction Steps

Following the procedure for Example 111 starting from tert-butyl ((3S,4R,7S)-3-fluoro-7-(1-methyl-4-nitro-1H-pyrazol-5-yl)oxepan-4-yl)carbamate (Intermediate 80), and replacing 5-((tert-butoxycarbonyl)amino)-2-(2,6-difluorophenyl)thiazole-4-carboxylic acid with 5-((tert-butoxycarbonyl)amino)-2-phenylthiazole-4-carboxylic acid (Example 6) gave 320. 1H NMR (400 MHz, DMSO-d6) δ 9.29 (s, 1H), 7.89-7.81 (m, 2H), 7.50-7.34 (m, 4H), 7.01-6.59 (m, 1H), 4.83 (dd, J=10.7, 3.5 Hz, 1H), 4.57-4.39 (m, 1H), 4.37-3.99 (m, 2H), 3.80-3.70 (m, 3H), 2.04 (d, J=13.7 Hz, 1H), 2.00-1.66 (m, 4H). LCMS (ES+) m/z 431 (M+1).

Provenance & Evidence