HCID 58182201, compound → HCID 86713951, compound

Participants

Reaction Steps

Following the procedure for Example 111 starting from tert-butyl ((3S,4R,7S)-3-fluoro-7-(1-methyl-4-nitro-1H-pyrazol-5-yl)oxepan-4-yl)carbamate (Intermediate 80), and replacing 5-((tert-butoxycarbonyl)amino)-2-(2,6-difluorophenyl)thiazole-4-carboxylic acid with 5-((tert-butoxycarbonyl)amino)-2-(2-(trifluoromethyl)phenyl)thiazole-4-carboxylic acid (Example 19) gave 323. 1H NMR (400 MHz, DMSO-d6) δ 9.05 (s, 1H), 7.87 (d, J=7.8 Hz, 1H), 7.81-7.73 (m, 3H), 7.70-7.64 (m, 1H), 7.43 (s, 2H), 4.74 (dd, J=11.0, 3.4 Hz, 1H), 4.50-4.30 (m, 1H), 4.19-3.89 (m, 2H), 3.76 (s, 3H), 2.06-1.97 (m, 1H), 1.91-1.79 (m, 1H), 1.76-1.66 (m, 2H). LCMS (ES+) m/z 499 (M+1).

Provenance & Evidence