反应详情

温度

120 °C

N-methyl-N-(phenylsulfonyl)-2-chloro-6-fluorobenzohydrazonoyl chloride (1.10 g), 4-butyl-2-chlorobenzonitrile (0.60 g) and anhydrous aluminum chloride (0.50 g) are added to o-dichlorobenzene (10 ml) and stirred at 120° C. for 1 hour. On completion of the reaction, chloroform (100 ml) is added and washed with dilute hydrochloric acid. After washing with water, the organic layer is dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The concentrate is purified by silica gel column chromatography using mixed solution of hexane-ethyl acetate as eluent to give 0.70 g of compound (refractive index: 1.5667).

1. additionis added
2. washwashed with dilute hydrochloric acid
3. washAfter washing with water
4. dry with materialthe organic layer is dried over anhydrous magnesium sulfate
5. concentrationconcentrated under reduced pressure
6. customThe concentrate is purified by silica gel column chromatography
7. additionusing mixed solution of hexane-ethyl acetate as eluent