Ethanolamine → HCID 118497047, compound

HRID 522099Notes

Reaction equation

HRID 522099 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([N:15]2[C:19]([NH:20][C:21](=[O:36])[C:22]3[CH:27]=[C:26]([C:28]4[C:33]([F:34])=[CH:32][CH:31]=[CH:30][N:29]=4)[CH:25]=[CH:24][C:23]=3[Cl:35])=[CH:18][C:17]([C:37](OCC)=[O:38])=[N:16]2)[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1.[CH2:42]([CH2:44][NH2:45])[OH:43]>>[Cl:35][C:23]1[CH:24]=[CH:25][C:26]([C:28]2[C:33]([F:34])=[CH:32][CH:31]=[CH:30][N:29]=2)=[CH:27][C:22]=1[C:21]([NH:20][C:19]1[N:15]([C:11]2[CH:12]=[CH:13][CH:14]=[C:9]([OH:8])[CH:10]=2)[N:16]=[C:17]([C:37]([NH:45][CH2:44][CH2:42][OH:43])=[O:38])[CH:18]=1)=[O:36]

Participants

3

Reactant 2

HCID 700EthanolamineHCID 118497063HCID 118497063, compound

Product 1

HCID 118497047HCID 118497047, compound

Procedure

The title compound was prepared according to the method described for Example 85 using ethyl 1-(3-(benzyloxy)phenyl)-5-(2-chloro-5-(3-fluoropyridin-2-yl)benzamido)-1H-pyrazole-3-carboxylate (Example 128) and ethanolamine. The residue was purified using reverse phase column chromatography eluting with 0-100% MeCN in water with 0.1% NH3.

Workup

  1. customThe residue was purified
  2. washeluting with 0-100% MeCN in water with 0.1% NH3

Sources & evidence

ORD record
ord-fd0d516fb7ea450ea22615c9f3a55c80
Source dataset
uspto-grants-2016_05
Patent number
US09328096B2

Reaction notes

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